https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32668 Wed 19 Jan 2022 15:16:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18377 Wed 11 Apr 2018 15:30:05 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26012 Wed 11 Apr 2018 14:44:48 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54220 65 years of age, 36 (8%) were children (< 16 years), 6 (1%) were Aboriginal and Torres Strait Islander peoples, 4 (1%) were pregnant and 289 (65%) had chronic comorbidities. COVID-19 hospital admissions peaked between weeks 13 and 15 (first wave) nationally, and again between weeks 31 and 35 (Victoria), with most admissions represented by those above 40 years of age. Discussion: There was an unusually low number of hospital admissions with laboratory-confirmed influenza in this season, compared to recent seasons. This is likely to be due to effective public health interventions and international border closures as a result of a rise in COVID-19 respiratory infections and associated hospitalisations.]]> Tue 13 Feb 2024 12:02:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8460 Sat 24 Mar 2018 08:38:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12440 Sat 24 Mar 2018 08:15:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23760 4 (LXA,sub>4) can also interact with ALX/FPR2 receptors and lead to allosteric inhibition of SAA-initiated epithelial responses (pA₂ 13 nM). During acute exacerbation, peripheral blood SAA levels increased dramatically and were disproportionately increased relative to LXA₄. Human lung macrophages (CD68⁺) colocalized with SAA and GCs markedly increased SAA in vitro (THP-1, pEC₅₀ 43 nM). To determine its direct actions, SAA was administered into murine lung, leading to induction of CXC chemokine ligand 1/2 and a neutrophilic response that was inhibited by 15-epi-LXA₄ but not dexamethasone. Taken together, these findings identify SAA as a therapeutic target for inhibition and implicate SAA as a mediator of GC-resistant lung inflammation that can overwhelm organ protective signaling by lipoxins at ALX/FPR2 receptors.]]> Sat 24 Mar 2018 07:11:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36574 Mon 24 Jul 2023 18:02:31 AEST ]]>